Error PS101 in QuickBooks typically points to a payroll update issue. It happens when the software cannot connect properly with the Intuit server or if system files are corrupted. Sometimes, firewall or antivirus settings may also block payroll updates, leading to this error. Users should verify that QuickBooks Desktop is running the latest release and ensure proper system configuration. Repairing the payroll setup and resetting the QuickBooks update components can help resolve this common payroll-related issue effectively.

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